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KMID : 0362720090470120830
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Journal of the Korean Dental Association
2009 Volume.47 No. 12 p.830 ~ p.837
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Clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) in periodontal disease : Double blind, randomized control study
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Chang Yun-Young
Kim Chang-Sung
Jung Ui-Won
Choi Seong-Ho
Kim Baek-Il
Um Yoo-Jung
Jung Im-Hee
Jang Yong-Ju
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Abstract
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Purpose : The purpose of this study was to evaluate the clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) for periodontal disease
Material and Methods : The study was performed by double blinded, ramdomized method. Forty two subjects diagnosed as chronic incipient or moderate periodontitis at department of periodontology, Yonsei Dental Hospital were included in the study. This study was approved by Institutional Review Board , Yonsei Universtiy Hospital.
All subjects received scaling at their first examination and second examination was scheduled after 2 weeks. At second
examination, periodontal parameters such as plaque index(PI), gingival index(GI), probing depth(PD), bleeding on probing(BOP), gingival recession(GR) and clinical attachment level(CAL) were recorded(Baseline) with prescription of Vitamin C, Vitamin E, lysozyme, carbazochrome complex(IGATAN®) (Experimental group 23 subjects) or placebo medicine(Control group; 19 subjects). The subjects were recalled after 4 weeks for periodontal parameters measurement.
Results : In the experimental groups, PI, GI, CAL and BOP scores were significantly reduced at 4 weeks compared to baseline. A statistically significant decrease in GI and BOP scores were observed in the experimental group compared to the control group.
Conclusion : It can be concluded that Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) have an effect in reducing gingival bleeding and improving periodontal inflammatory condition inchronic incipient- moderate periodontitis.
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KEYWORD
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Vitamin C, Vitamin E, lysozyme, carbazochrome
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